Pickles and colorectal cancer.

The association with pickles was examined in 3 Japanese cohorts.
Cancer risk: No association was found with colon, or rectal cancer risk (24).
Cancer mortality: Data about cancer mortality was provided by 2 cohorts. In one cohort, a significant protective effect against colon cancer mortality was found among men, but not women (22). And in one cohort of very small size, a significant protective effect against total colorectal cancer mortality was found among men, but not women (21). No associations were found with rectal cancer mortality (22).

Conclusion: Some significant protective effects against different mortality end points were found among men, but one cohort was of very small size. Evidence is suggestive for a protective effect of pickles against colorectal cancer mortality among men.

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Author

Cohort name

Subjects

Years of follow-up

Cases

End point

Consumption of

Relative Risk (RR)

Adjustments

24) Sato Y. (2005)

The Miyagi Cohort Study.

47,605 subjects (22,836 men and 24,769 women) aged 40-64.
(Japan)

1990-1997

Colon: 165?
Rectal: 110?

Colon, and rectal cancer risk

Tsukemono (pickles)

No significant correlation was found with colon, and rectal cancer risk (No data shown).

Sex, age, smoking status, alcohol consumption, BMI, education, family history of cancer, walking time, and meat consumption.

22) Iso H (2007)

The JACC Study.

43,035 men, and 59,196 women.
(Japan)

Not defined.

199 men, and
202 women.

Colon cancer mortality

Pickles


Men:	Women:
HR = 0.65 (0.47-0.90; P = < 0.01) for the highest vs lowest tertile of consumption. Amount specific data: < 3/w: HR = 1. 3-4/w: HR = 0.88 (0.58-1.35). ≥ 5/w: HR = 0.65 (0.47-0.90).	HR = 0.91 (0.64-1.27) for the highest vs lowest tertile of consumption. Amount specific data: < 3/w: HR = 1. 3-4/w: HR = 0.92 (0.57-1.49). ≥ 5/w: HR = 0.91 (0.64-1.27).

Age and study area.

22) Iso H (2007)

The JACC Study.

43,035 men, and 59,196 women.
(Japan)

Not defined.

157 men, and
76 women.

Rectal cancer mortality

Pickles


Men:	Women:
HR = 0.91 (0.61-1.34) for the highest vs lowest tertile of consumption. Amount specific data: < 3/w: HR = 1. 3-4/w: HR = 1.05 (0.63-1.73). ≥ 5/w: HR = 0.91 (0.61-1.34).	HR = 0.88 (0.49-1.58) for the highest vs lowest tertile of consumption. Amount specific data: < 3/w: HR = 1. 3-4/w: HR = 1.11 (0.52-2.39). ≥ 5/w: HR = 0.88 (0.49-1.58).

Age and study area.

21) Khan MM. (2004)

No cohort name.

1,524 men and 1,634 women aged ≥ 40 living in Hokkaido, Japan.

1984-2002

15 men, 14 women?

Colorectal cancer mortality

Japanese pickle

Men: RR = 0.2 (0.1-0.8; P = < 0.05).
Women: Not estimated due to 0 case in either of the 2 groups.

RRs are for consumption ≥ several times/wk vs ≤ several times/month.

Men: age and smoking. Women: age, health status, health education, health screening + smoking.

Cancer & Diet. A systematic review.

Literature review.

Relating various aspects of our diet
to colorectal cancer risk & mortality.

Pickles and colorectal cancer.

Cancer & Diet. A systematic review.

Literature review.

Relating various aspects of our dietto colorectal cancer risk & mortality.

Pickles and colorectal cancer.

Relating various aspects of our diet
to colorectal cancer risk & mortality.